Key result
Fluoxetine and its metabolite norfluoxetine cause drug-induced long QT syndrome by both acutely inhibiting the hERG channel and disrupting the normal trafficking of hERG protein to the cell membrane.
Population
In vitro hERG channels and a clinical case of QTCI prolongation
Design
Editorial
Authors
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Fluoxetine-induced long QT syndrome may be mediated by both acute hERG channel blockade and disruption of hERG protein trafficking, highlighting potential limitations of relying solely on acute screening methods for assessing QTcI prolonging liability.
Fluoxetine-induced long QT syndrome may be mediated by both acute hERG channel blockade and disruption of hERG protein trafficking, highlighting potential limitations of relying solely on acute screening methods for assessing QTcI prolonging liability.
Hancox et al. (2006) conducted an editorial in Drug-induced long QT syndrome. Fluoxetine was evaluated on hERG channel inhibition and trafficking disruption. Fluoxetine and its metabolite norfluoxetine cause drug-induced long QT syndrome by both acutely inhibiting the hERG channel and disrupting the normal trafficking of hERG protein to the cell membrane.
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