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May 1, 1958American Journal of Physiology-Legacy Content

Na24 and K42 Exchange in Atrial Fibrillation

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Key result

Acetylcholine-induced fibrillation transiently increases K efflux ~172% and drives profound Na influx versus control.

Population

Atrial tissue model (specific animal or tissue source not stated in abstract)

Comparison

Acetylcholine (ACh) induced fibrillation vs Control state, ACh alone, or stimulation alone

Design

Preclinical

Authors

RKRichard L. KleinMedical University of South CarolinaWHWilliam C. HollandNational Oceanic and Atmospheric Administration

Discussion

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Implication

Transient K/Na flux surges in ACh-induced atrial fibrillation do not inform clinical management; leaves open distinct initiation versus maintenance mechanisms.

Structured PICO

P
Population
Atrial tissue model (specific animal or tissue source not stated in abstract)
I
Intervention
Acetylcholine (ACh) induced fibrillation
C
Comparator
Control state (mean atrial rate 160/min), ACh alone, or stimulation alone
O
Outcome
Transmembrane flux of Na24 and K42surrogate

Main Result

Absolute Event Rate: 9.37% vs 3.45%

Acetylcholine and fibrillation transiently increase the transmembrane flux of Na and K, suggesting that the initiation and maintenance of atrial fibrillation are governed by separate physicochemical processes.

Cite This Study

Klein et al. (1958) studied Atrial Fibrillation. Acetylcholine (ACh) induced fibrillation vs. Control (mean atrial rate of 160/min) was evaluated on K efflux (pmole/cm2sec). Acetylcholine-induced fibrillation transiently increased K efflux from 3.45 to 9.37 pmole/cm2sec and increased Na influx 10-15 times compared to control.

synapsesocial.com/papers/6aa555d7f8a2a3c96b39591ahttps://doi.org/10.1152/ajplegacy.1958.193.2.239

Topics

Atrial fibrillationPersistent AF management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fibrillation and Potassium Influx1959 · 15 citations
  2. 2Fibrillation and Potassium Influx1959 · 2 citations
  3. 3Potassium Exchange in Atrial Fibrillation1957 · 22 citations
  4. 4Factors Affecting the Incidence of Atrial Fibrillation1958 · 12 citations
  5. 5REMODELING OF Na,K-ATPase, AND MEMBRANE FLUIDITY AFTER ATRIAL FIBRILLATION IN SHEEP2002 · 9 citations