Key result
Conscious sedation for TAVI is linked to ~90% lower inotrope use versus general anaesthesia.
Why the study?
Does conscious sedation improve procedural efficiency and reduce inotrope requirement compared to general anaesthesia in patients undergoing transfemoral aortic valve implantation?
Population
88 patients undergoing transfemoral transcatheter aortic valve implantation at a single UK centre
Comparison
Conscious sedation vs General anaesthesia
Design
Cohort
Authors
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May support conscious sedation to reduce inotrope use in transfemoral TAVI; hypothesis-generating, requires randomized confirmation before practice change.
Observational (n=88)
No
Does conscious sedation improve procedural efficiency and reduce inotrope requirement compared to general anaesthesia in patients undergoing transfemoral aortic valve implantation?
Odds Ratio: 0.1 (95% CI 0.002–0.05)
Absolute Event Rate: 4.6% vs 81.8%
p-value: p=<0.001
Conscious sedation is a feasible alternative to general anaesthesia for transfemoral TAVI, associated with improved efficiency and reduced need for inotropic support.
Miles et al. (2016) conducted an observational in Transfemoral aortic valve implantation (n=88). Conscious sedation vs. General anaesthesia was evaluated on Requirement for inotropes (OR 0.1, 95% CI 0.002-0.050, p=<0.001). Conscious sedation for transfemoral aortic valve implantation was associated with a lower requirement for inotropes compared to general anaesthesia (4.6% vs 81.8%; OR 0.1; 95% CI 0.002-0.050; p<0.001).
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