Key result
Alloxan diabetes reduces protein synthesis ~30% in perfused hearts, driven by lower RNA concentration and efficiency.
Population
Hearts perfused as Langendorff or working preparations, and isolated heart muscle cells, from models with…
Comparison
Alloxan diabetes and perfusion with buffers… vs Control hearts perfused with buffers simulating…
Design
Preclinical
Follow-up
10 days
Authors
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Diabetes impairs rat cardiac protein balance resistant to insulin; hypothesis-generating for human diabetic cardiomyopathy mechanisms.
Long-term diabetes induces a negative nitrogen balance in cardiac muscle through decreased protein synthesis and increased degradation that is resistant to normalization by insulin or cardiac work.
Williams et al. (1980) studied Alloxan diabetes. Alloxan diabetes vs. Control was evaluated on Protein synthesis. Alloxan diabetes of 10-day duration produced a 30% inhibition of protein synthesis in perfused hearts, attributable to a 20% fall in RNA concentration and a 10% decrease in efficiency.
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