What question did this study set out to answer?

To profile the gut microbiome of a large cohort of patients to identify distinct microbial signatures associated with irritable bowel syndrome and its subtypes.

August 4, 2015Scientific ReportsOpen Access

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome

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Authors

MPMarta PozueloVall d'Hebron Hospital Universitari SPSuchita PandaRoyal Cornhill Hospital ASAlba SantiagoPopulation Health Research Institute

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Implication

Case-control study reveals marked depletion of butyrate- and methane-producing microbes in irritable bowel syndrome, suggesting impaired gut barrier integrity and reduced hydrogen gas clearance.

Key Points

To profile the gut microbiome of a large cohort of patients to identify distinct microbial signatures associated with irritable bowel syndrome and its subtypes.
Examined 273 fecal samples from 113 patients with IBS and 66 healthy controls, including a subset providing repeat samples one month apart.
Generated over 20 million 16S rRNA gene sequences to evaluate taxonomic abundance, overall microbial diversity, and clinical symptom associations.
IBS patients, particularly those with IBS-D and IBS-M subtypes, showed significantly lower microbial diversity linked to reduced butyrate-producing bacteria (P = 0.002; q < 0.06).
Untreated IBS patients exhibited significantly lower Methanobacteria abundance than healthy controls (P = 0.005; q = 0.05), with multiple bacterial taxa correlating with flatulence and abdominal pain severity (P < 0.05).

Cite This Study

Pozuelo et al. (2015) studied this question.

synapsesocial.com/papers/6aa562b13f91f0dc5278ed11 https://doi.org/10.1038/srep12693

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Implication

Case-control study reveals marked depletion of butyrate- and methane-producing microbes in irritable bowel syndrome, suggesting impaired gut barrier integrity and reduced hydrogen gas clearance.

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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