Pancreatitis and Phenformin

Letters, Comments, and Corrections1 August 1972Pancreatitis and PhenforminHENRY WILDE, M.D., F.A.C.P.HENRY WILDE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-2-324_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Phenformin therapy may be associated with a metallic taste, anorexia, nausea, and occasional diarrhea with abdominal cramps. This is adequately discussed in the drug's package insert. A recent review of chronic pancreatitis (1) fails to mention phenformin or other oral hypoglycemic agents as possible causes of pancreatitis. The University Group Diabetes Program (2) and a recent rebuttal (3) have scrutinized phenformin and its possible association with a higher incidence of cardiovascular deaths, but neither report mentioned any cases of relapsing pancreatitis. We report briefly our recent experience with a patient with early-maturity-onset diabetes who was managed with...References1. STRUM W and SPIRO H: Chronic pancreatitis. Ann Intern Med 74:264-277, 1971 LinkGoogle Scholar2. KNATTERUD G, MEINERT C, and KLIMT C: Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. IV. A preliminary report on phenformin results. JAMA 217:777-784, 1971 CrossrefMedlineGoogle Scholar3. TZAGOURNIS M and REYNERTSON R: Mortality from coronary heart disease during phenformin therapy. Ann Intern Med 76:587-592, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HENRY WILDE, M.D., F.A.C.P.Affiliations: Medical Service U.S. Diplomatic Mission Medical Unit and U.S. Army Hospital Bangkok, Thailand PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA systematic review of acute pancreatitis as an adverse event of type 2 diabetes drugs: from hard facts to a balanced positionDrug-Induced PancreatitisDrug-Induced Gastrointestinal DisordersDrug-induced pancreatitis: A critical reviewEtiology of Acute PancreatitisDrug-induced gastrointestinal diseasePhenformin and Hyperamylasemia in Lactic AcidosisLYDIA A. CONLAY, M.D., JOSEPH E. LOEWENSTEIN, M.D., F.A.C.P.Phenformin-Associated PancreatitisHERBERT S. CHASE Jr., M.D., GLEN R. MOGAN, M.D.Phenformin and PancreatitisALEXANDER A. LEVITAN, M.D., M.P.H. 1 August 1972Volume 77, Issue 2Page: 324-324KeywordsChronic pancreatitisDiarrheaDrugsHypoglycemicsNauseaPancreatitisTaste ePublished: 1 December 2008 Issue Published: 1 August 1972 PDF downloadLoading ...