Acute Pancreatitis Secondary to Hypercalcemia of Multiple Myeloma

Case Studies1 December 1962Acute Pancreatitis Secondary to Hypercalcemia of Multiple MyelomaLAWRENCE E. MELTZER, M.D., FLORENTINO P. PALMON JR., M.D., YOUNG K. PAIK, M.D., R. PHILIP CUSTER, M.D.LAWRENCE E. MELTZER, M.D.Search for more papers by this author, FLORENTINO P. PALMON JR., M.D.Search for more papers by this author, YOUNG K. PAIK, M.D.Search for more papers by this author, R. PHILIP CUSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-1008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe observation by Cope, Culver, Mixter, and Nardi (1) in 1957 that pancreatitis may complicate hyperparathyroidism has been amply confirmed. More than 60 cases in which these 2 states existed concomitantly have been reported (2, 3). This etiologic relationship appears to be well enough established to warrant the advice that patients with pancreatitis be studied appropriately in order to exclude hyperparathyroidism, even when the more common manifestations of this disease are absent (4).The mechanism by which pancreatitis occurs in the presence of hyperparathyroidism has not been fully explained and remains controversial. Several hypotheses have been presented. It has been...References1. COPECULVERMIXTERNARDI OPJCGGL: Pancreatitis, diagnostic clue to hyperparathyroidism. Ann. Surg. 145: 857, 1957. CrossrefMedlineGoogle Scholar2. MIXTERKEYNESCOPE CGMO: Further experience with pancreatitis as a diagnostic clue to hyperparathyroidism. New Engl. J. Med. 266: 265, 1962. CrossrefGoogle Scholar3. KEYNES M: Pancreatitis and hyperparathyroidism. Lancet 1: 859, 1962. CrossrefGoogle Scholar4. TURCHIFLANDREAUFORTEFRENCHLUDWIG JJRHALGNGD: Hyperparathyroidism and pancreatitis. JAMA 180: 799, 1962. CrossrefMedlineGoogle Scholar5. HEUPER W: Metastatic calcifications in organs in dog after injection of parathyroid extract. Arch. Path. 3: 14, 1927. Google Scholar6. HAVERBACKDYCEBUNDYEDMONDSON BJBHHA: Trypsin, trypsinogen and trypsin inhibitor in human pancreatic juice: mechanism for pancreatitis associated with hyperparathyroidism. Amer. J. Med. 29: 424, 1960. CrossrefGoogle Scholar7. PLOUGHKYLE ICLH: Pancreatic insufficiency and hyperparathyroidism. Ann. Intern. Med. 47: 590, 1957. LinkGoogle Scholar8. ALDIS AS: Clinical experiences of lesser known manifestations of hyperparathyroidism. Proc. Roy. Soc. Med. 54: 489, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Section of Clinical Investigation and the Department of Pathology, The Presbyterian Hospital in Philadelphia.This work was conducted under grants from the John A. Hartford Foundation, Inc., New York, New York.Requests for reprints should be addressed to Lawrence E. Meltzer, M.D., Section of Clinical Investigation, The Presbyterian Hospital in Philadelphia, 51 North 39th Street, Philadelphia 4, Pennsylvania. 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STRUM, M.D., HOWARD M. SPIRO, M.D.Prim�rer Hyperparathyreoidismus und exokrine PankreasfunktionAcute pancreatitis in gynecologic and obstetric practiceNiere bei Tumoren, Blutkrankheiten und ParaproteinämienPancreatitis Associated with Primary HyperparathyroidismHemorrhagic PancreatitisCalciphylaxiepankreatitis und PankreatitispathogeneseCase 63-1963Primary Hyperparathyroidism: Problems for Clinician and ChemistE. J. H. 1 December 1962Volume 57, Issue 6Page: 1008-1012KeywordsAcute pancreatitisCalciumClinical pathologyHypercalcemiaHyperparathyroidismHypoproteinemiaMultiple myelomaPancreatitis Issue Published: 1 December 1962 PDF DownloadLoading ...