Key result
Chronic HCV infection is linked to cardiopulmonary manifestations including myocarditis, cardiomyopathy, and CVD.
This review highlights the broad spectrum of cardiopulmonary extrahepatic manifestations associated with chronic HCV infection and the potential for antiviral therapy-related toxicity.
HCV-associated cardiac EHMs merit consideration in unexplained cardiomyopathy; leaves open causal links and antiviral impact on cardiac outcomes.
Besides liver cirrhosis and hepatocellular carcinoma, chronic hepatitis C virus (HCV) infection is associated with many extrahepatic manifestations (EHMs). HCV exhibits lymphotropism that is responsible for various EHM. An important characteristic of HCV is escape from the immune system, which enables it to produce chronic infections and autoimmune disorders along with accumulation of circulating immune complexes. These EHMs have large spectrum, because they affect many organs such as heart, lungs, kidney, brain, thyroid, and skin. HCV-related cardiac and pulmonary manifestations include myocarditis, cardiomyopathies, cardiovascular diseases (i.e., Stroke, ischemic heart disease), chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, asthma, and interstitial lung diseases. This review discusses etiology and pathogenesis of HCV-associated cardiac and pulmonary manifestations and how different genes, immune system, indirectly linked factors (mixed cryoglobulinemia), liver cirrhosis, and antiviral treatment are involved in HCV-related heart and lung diseases, however, their exact mechanism is not clear.
No takes yet. Share an insight, caveat, or question.
Ilyas et al. (2017) conducted a review in Chronic hepatitis C virus (HCV) infection. Hepatitis C Virus (HCV) infection was evaluated. Chronic hepatitis C virus infection is associated with cardiac and pulmonary extrahepatic manifestations, including myocarditis, cardiomyopathies, and cardiovascular diseases.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: