September 1, 2010Journal of Cardiovascular Medicine
Aortic root surgery in Marfan syndrome: Bentall procedure with the composite mechanical valved conduit versus aortic valve reimplantation with Valsalva graft
Key result
Bentall procedure shows similar 8-year survival to aortic valve reimplantation in Marfan syndrome patients.
- P NS
- n=47
Why the study?
Does the Bentall procedure compared to aortic valve reimplantation improve mid-term outcomes in patients with Marfan syndrome and aortic root aneurysm?
Population
47 patients with Marfan syndrome and aortic root aneurysm
Comparison
Bentall aortic root replacement with composite… vs Aortic valve reimplantation procedure using the…
Design
Cohort
Follow-up
mean 65 +/- 44 months
Authors
Discussion
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Implication
Both techniques yield comparable mid-term outcomes in selected Marfan patients; leaves open prospective trials on long-term durability and selection criteria.
Study Design
Type
Cohort (n=47)
Structured PICO
Does the Bentall procedure compared to aortic valve reimplantation improve mid-term outcomes in patients with Marfan syndrome and aortic root aneurysm?
P
Population
47 patients with Marfan syndrome and aortic root aneurysm who underwent either the Bentall procedure or aortic valve reimplantation, followed for a mean of 65 months.
E
Exposure
Bentall aortic root replacement with composite mechanical valved conduit
C
Comparator
Aortic valve reimplantation procedure using the Valsalva graft
O
Outcome
Mid-term survival, freedom from cardiac death, and freedom from reoperationhard clinical
Main Result
Absolute Event Rate: 91% vs 100%
p-value: p=NS
Both the Bentall procedure and aortic valve reimplantation provide excellent and comparable mid-term survival and freedom from reoperation in Marfan syndrome patients with aortic root aneurysms.
Cite This Study
Nardi et al. (2010) conducted a cohort in Aortic root aneurysm in Marfan syndrome (n=47). Bentall procedure with composite mechanical valved conduit vs. Aortic valve reimplantation with Valsalva graft was evaluated on Eight-year survival (p=NS). The Bentall procedure and aortic valve reimplantation yielded similar 8-year survival (91% vs 100%, P=NS) and freedom from cardiac death (96% vs 100%, P=NS) in Marfan syndrome patients.