Key result
Stenting de novo lesions is linked to higher post-stent hsCRP versus ISR, reflecting morphological differences.
Why the study?
Does stent implantation in de novo lesions compared to intrastent restenosis lesions result in a different inflammatory response in patients with stable angina?
Observational (n=226)
Does stent implantation in de novo lesions compared to intrastent restenosis lesions result in a different inflammatory response in patients with stable angina?
Stent implantation in de novo lesions triggers a greater inflammatory response than in ISR lesions, which correlates with a higher proportion of necrotic core and fibrofatty tissue.
Does not support lesion-specific anti-inflammatory strategies in stable angina; leaves open morphology-driven inflammation effects on outcomes.
Mechanical plaque rupture of coronary atherosclerotic plaque during stent implantation can increase serum levels of high-sensitivity C-reactive protein (hsCRP). Patients with stable angina pectoris were divided into 2 groups: one group included 186 patients with de novo lesion who underwent stent implantation (de novo group); the other group included 40 patients with intrastent restenosis (ISR) undergoing stent implantation (ISR group). The de novo group had a significant increase in hsCRP levels post stenting, while the ISR group showed no increase in hsCRP post stenting. Intravascular ultrasound with radiofrequency data analysis showed that the de novo group had larger percentage of both necrotic core area and fibrofatty area at the target lesion than the ISR group, while the ISR group had a larger percentage of fibrous area. Differential inflammatory response to stent implantation between the de novo plaque and in ISR lesion is related to lesion morphology.
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Hikita et al. (2011) conducted an observational in Stable angina pectoris (n=226). De novo lesion vs. Intrastent restenosis (ISR) lesion was evaluated on Increase in hsCRP levels post stenting. Stent implantation in de novo lesions significantly increased hsCRP levels post-stenting, whereas intrastent restenosis lesions showed no increase, reflecting differences in lesion morphology.
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