Key result
ANP may require dopamine to exert its diuretic and natriuretic effects in volume-expanded rats.
Dopamine acts as a necessary permissive agent for the renal diuretic and natriuretic effects of ANP to manifest, independent of ANP-stimulated guanylate cyclase activation.
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Does not support changes in human diuretic therapy; leaves open dopamine-ANP synergy in clinical volume regulation.
Katoh et al. (1989) studied Volume-expanded rats. Atrial natriuretic peptide (ANP) and dopamine antagonists was evaluated on Urine volume, urine Na excretion, fractional excretion of Na, GFR, and RPF. Dopamine may be necessary as a permissive agent for the renal diuretic and natriuretic effects of atrial natriuretic peptide to manifest in volume-expanded rats.
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