Key result
Berberine is linked to improved lipids, fasting glucose, body weight, and endothelial function versus standard care.
Why the study?
Berberine was evaluated to assess lipid control and the early evolution of subclinical atherosclerosis in otherwise healthy subjects with borderline hyperlipidemia not taking drugs.
Does oral berberine supplementation improve lipid profiles and prevent early atherosclerosis evolution in otherwise healthy subjects with borderline hyperlipidemia?
Cohort
Does oral berberine supplementation improve lipid profiles and prevent early atherosclerosis evolution in otherwise healthy subjects with borderline hyperlipidemia?
p-value: p=<0.05
Oral berberine supplementation for 6 months improves lipid profiles, metabolic parameters, and markers of subclinical atherosclerosis in subjects with borderline hyperlipidemia.
Berberine was associated with improved lipids and endothelial function in borderline hyperlipidemia; hypothesis-generating and should not yet change practice.
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Cesarone et al. (2025) conducted a cohort in Borderline hyperlipidemia. Berberine supplementation vs. Standard management (SM) was evaluated on Total cholesterol (p=<0.05). Berberine supplementation for 6 months significantly improved lipid profiles, fasting glucose, body weight, and endothelial function compared to standard management alone (P<0.05).
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