Enhanced Synthesis of Phosphatidylethanolamine in Chick Embryo Cells Infected with Sendai Virus of Parainfluenza Type 1

ABSTRACT 3H‐Serine principally labeled phosphatidylserine (PS) and phosphatidylethanolamine (PE) of lipids of chick embryo cells. 3H‐Ethanolamine labeled almost entirely PE of lipids of the cells. In turnover experiment with 3H‐serine incorporated into cells before infection, the pathway from PS to PE was shown to become more active by Sendai virus infection. Similar turnover experiment using 3H‐ethanolamine revealed that PE synthesis directly utilizing ethanolamine was also slightly enhanced by the infection. The most marked difference of infected cells from control cells was the enhanced rate of 3H‐serine incorporation into lipids. These results indicated that the Sendai virus infection enhanced the metabolic pathway serine–PS–PE.