Key result
New essential hypertension is linked to ~64% higher serum H-FABP levels, driven by arterial stiffness.
Why the study?
Is arterial stiffness associated with serum H-FABP levels (a marker of myocardial damage) in patients with newly diagnosed essential hypertension?
Case-Control (n=86)
Is arterial stiffness associated with serum H-FABP levels (a marker of myocardial damage) in patients with newly diagnosed essential hypertension?
Absolute Event Rate: 21.1% vs 12.9%
p-value: p=0.002
Increased arterial stiffness in newly diagnosed essential hypertension is independently associated with elevated serum H-FABP levels, suggesting early subclinical myocardial damage.
May indicate early myocardial injury from stiffness in new hypertension; leaves open whether targeting stiffness alters outcomes.
BACKGROUND: Arterial stiffness increases in hypertensive individuals. Arterial stiffness is associated with impairment of systolic and diastolic myocardial function in hypertension (HT). However, the relationship between arterial stiffness and serum heart-type fatty acid-binding protein (H-FABP) levels, a sensitive marker of myocardial damage, has not been previously examined in patients with HT. We investigate the relationship between serum H-FABP levels and arterial stiffness in patients with newly diagnosed HT. METHODS: We studied 46 (48.5 +/- 10.6, years) never-treated patients with HT and age-matched control group of 40 (47 +/- 8.6, years) normotensive individuals. H-FABP levels were determined in all subjects. We evaluated arterial stiffness and wave reflections of study population, using applanation tonometry (Sphygmocor). Carotid-femoral pulse wave velocity (PWV) was measured as indices of elastic-type, aortic stiffness. The heart rate-corrected augmentation index (AIx@75) was estimated as a marker of wave reflections. RESULTS: Carotid-femoral PWV (10.5 +/- 2.2 vs. 8.7 +/- 1.6, m/s, P = 0.0001) and AIx@75 (22.7 +/- 9.5 vs. 15 +/- 11, %, P = 0.001) were significantly higher in patients with HT than control group. H-FABP levels were increased in hypertensive patients compared with control group (21.1 +/- 14.8 vs. 12.9 +/- 8.5, ng/ml, P = 0.002). In multiple linear regression analysis, we found that the body mass index (beta = 0.42, P = 0.0001) and carotid-femoral PWV (beta = 0.23, P = 0.03) were significant determinants of H-FABP levels. CONCLUSION: Arterial stiffness is associated with serum H-FABP levels, a sensitive marker of myocardial damage, in patients with newly diagnosed HT.
No takes yet. Share an insight, caveat, or question.
Gedikli et al. (2008) conducted a case-control in Newly diagnosed essential hypertension (n=86). Newly diagnosed essential hypertension vs. Normotensive individuals was evaluated on Serum H-FABP levels (p=0.002). Newly diagnosed essential hypertension was associated with higher serum H-FABP levels compared to normotensive controls (21.1 vs 12.9 ng/ml, P=0.002), and arterial stiffness was a significant determinant of H-FABP.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: