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September 1, 2026American Heart Journal Plus Cardiology Research and PracticeOpen Access

Prospective randomized clinical trial on comprehensive cardiac rehabilitation combined with individualized cognitive training in older adults with heart failure and mild cognitive impairment

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Why the study?

Randomized controlled trials of comprehensive cardiac rehabilitation in hospitalized acute heart failure patients remain limited, and cognitive assessment has not been their primary focus.

Does adding individualized cognitive training to comprehensive cardiac rehabilitation improve cognitive scores in older adults hospitalized for heart failure with mild cognitive impairment?

Population

Hospitalized HF patients aged >=65 yr with mild cognitive impairment undergoing CCR

Comparison

CCR plus individualized cognitive training using BrainHQ vs CCR alone

Design

Single center, prospective, open-label, randomized controlled superiority trial

Follow-up

Within 12 months after discharge

Key result

This ongoing trial will evaluate whether adding individualized cognitive training to comprehensive cardiac rehabilitation can prevent in-hospital cognitive decline in older adults with heart failure.

Authors

KIKodai IshiharaKIKazuhiro P. IzawaYNYoshitaka Naito

Discussion

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Overview

No practice change yet in HF; this RCT will test whether cognitive training added to rehab prevents in-hospital decline.

Study Design

Type

RCT

Blinding

Open-label

Randomization

1:1

Multicenter

No

Structured PICO

Does adding individualized cognitive training to comprehensive cardiac rehabilitation improve cognitive scores in older adults hospitalized for heart failure with mild cognitive impairment?

P
Population
Older adults aged ≥65 years hospitalized for heart failure with mild cognitive impairment undergoing comprehensive cardiac rehabilitation.
I
Intervention
Comprehensive cardiac rehabilitation (CCR) plus individualized cognitive training using BrainHQ (20 min/day, 5 days/week, for at least 2 weeks).
C
Comparator
Comprehensive cardiac rehabilitation (CCR) alone.
O
Outcome
Change in MoCA-J score from baseline to discharge.surrogate

This trial protocol outlines a study to determine if adding individualized cognitive training to comprehensive cardiac rehabilitation can prevent in-hospital cognitive decline in older adults with heart failure and mild cognitive impairment.

Cite This Study

Ishihara et al. (2026) conducted an RCT in Heart failure and mild cognitive impairment. Comprehensive cardiac rehabilitation plus individualized cognitive training (BrainHQ) vs. Comprehensive cardiac rehabilitation alone was evaluated on Change in MoCA-J score from baseline to discharge. This ongoing trial will evaluate whether adding individualized cognitive training to comprehensive cardiac rehabilitation can prevent in-hospital cognitive decline in older adults with heart failure.

synapsesocial.com/papers/6aa5832366012019823a4f93https://doi.org/10.1016/j.ahjo.2026.100889
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating the efficacy of dual-task training in older patients with chronic heart failure and comorbid cognitive frailty: a protocol for a randomized controlled trial2026
  2. 2Cognitive Training Intervention for Heart Failure Patients: A Randomised Controlled Trial2025 · 1 citations
  3. 3Benefit of cardiac rehabilitation in acute heart failure patients with cognitive impairment2024 · 3 citations
  4. 4Mild cognitive impairment in patients with acute heart failure does not limit the effectiveness of early phase II cardiac rehabilitation2021 · 5 citations
  5. 5Can Computerized Cognitive Training Improve Cognition in Patients With Heart Failure?2018 · 19 citations