Why the study?
It was unclear whether mild cognitive impairment diminishes the benefit of early phase II cardiac rehabilitation in patients hospitalized for heart failure.
Does mild cognitive impairment diminish the benefit of early phase II cardiac rehabilitation on physical function and ADLs in older patients hospitalized for acute heart failure?
Population
204 hospitalized HF patients undergoing CR in Japan
Comparison
Patients with MCI (MMSE 19-26) vs non-MCI (MMSE >26)
Design
Case-control study
Key result
Mild cognitive impairment did not significantly limit the effectiveness of early phase II cardiac rehabilitation in patients with acute heart failure, with no significant differences in 6-minute walking distance or Barthel Index at discharge compared to patients with normal cognitive function.
Authors
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Early phase II cardiac rehabilitation may benefit acute heart failure patients with mild cognitive impairment; leaves open randomized confirmation of functional gains.
Case-Control (n=204)
No
Does mild cognitive impairment diminish the benefit of early phase II cardiac rehabilitation on physical function and ADLs in older patients hospitalized for acute heart failure?
Absolute Event Rate: 245.8% vs 267.3%
p-value: p=0.309
Guideline-based early phase II cardiac rehabilitation improves physical function and ADLs in older patients with acute heart failure, regardless of the presence of mild cognitive impairment.
Yokota et al. (2021) conducted a case-control in Acute heart failure (n=204). Mild cognitive impairment vs. Normal cognitive function was evaluated on 6-minute walking distance (6MWD) at discharge (after propensity score matching) (95% CI -20.182 to 63.108, p=0.309). Mild cognitive impairment did not significantly limit the effectiveness of early phase II cardiac rehabilitation in patients with acute heart failure, with no significant differences in 6-minute walking distance or Barthel Index at discharge compared to patients with normal cognitive function.