Effect of cardiac rehabilitation on cognitive function in elderly patients with cardiovascular diseases
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Key result
Monthly cardiac rehabilitation is linked to a ~1.5-point improvement in MMSE cognitive scores.
- Effect estimate 1.455
- 95% CI 0.747-2.163
- P<0.001
- n=66
Why the study?
Cognitive function is an important factor for secondary prevention in elderly patients with cardiovascular diseases, but the impact of cardiac rehabilitation on cognitive improvement was unclear.
Population
66 elderly patients (≥70 years) with cardiovascular diseases
Comparison
Monthly cardiac rehabilitation (≥1/month) vs no monthly cardiac rehabilitation
Design
Prospective observational study
Follow-up
6 months
Authors
Discussion
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Implication
May support monthly cardiac rehab for cognitive gains in elderly CVD; hypothesis-generating and requires RCT confirmation before practice change.
Study Design
Type
Observational (n=66)
Blinding
Single-blind
Multicenter
No
PICO
P
Population
66 elderly patients (≥70 years old) with cardiovascular diseases enrolled in a cardiac rehabilitation program, followed for 6 months.
E
Exposure / Comparator
Monthly cardiac rehabilitation vs Non-monthly cardiac rehabilitation (At least once per month (30 min supervised aerobic exercise))
O
Primary Outcome
Change in Mini-mental State Examination (MMSE) score at 6 months — Effect estimate 1.455 (0.747-2.163), p=<0.001
Main Result
Mean Difference: 1.455 (95% CI 0.747–2.163)
Absolute Event Rate: 2.3% vs -0.1%
p-value: p=<0.001
Limitations
- Observational study with a small-sized specific cohort from a single center
- The type of cardiovascular disease in the cohort varied
- Short study period of only 6 months
- The observational design cannot establish a definitive causal relationship between cardiac rehabilitation and cognitive improvement
Cite This Study
Fujiyoshi et al. (2020) conducted an observational in Cardiovascular diseases (n=66). Monthly cardiac rehabilitation vs. Non-monthly cardiac rehabilitation was evaluated on Change in Mini-mental State Examination (MMSE) score at 6 months (Effect estimate 1.455, 95% CI 0.747-2.163, p=<0.001). Monthly cardiac rehabilitation significantly improved cognitive function in elderly patients with cardiovascular diseases, with an adjusted mean difference in MMSE score change of 1.455 points compared to non-monthly rehabilitation.
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