What is the clinical evidence from this study?

Study design: Observational. Population: Disseminated Intravascular Coagulation (DIC) (n=64). Intervention: Disseminated intravascular coagulation. Primary outcome: Incidence of fresh cardiac lesions.

What does this research mean for the field?

Fresh cardiac lesions occur in 62.5% of autopsy cases with disseminated intravascular coagulation, frequently manifesting as myocardial necrosis (37.5%) and coronary thrombosis (20.3%). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1977Japanese Heart JournalOpen Access

A Clinicopathological Study on Cardiac Lesions in 64 Cases of Disseminated Intravascular Coagulation

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Key result

Disseminated intravascular coagulation is linked to fresh cardiac lesions in ~63% of autopsies.

n=64

Why the study?

What is the incidence and nature of cardiac lesions in patients with disseminated intravascular coagulation?

Population

64 autopsy cases with disseminated intravascular coagulation out of 395 total autopsy cases, 31 men and 33…

Design

Cohort

Authors

MSMasaya SugiuraTokyo University of Agriculture and Technology KHKeisuke HiraokaHyogo Medical University SOShin-ichiro OhkawaTokyo Medical and Dental University

Discussion

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Implication

Disseminated intravascular coagulation is frequently associated with fresh cardiac lesions, including coronary thrombosis and myocardial necrosis, particularly in elderly patients.

Study Design

Type

Observational (n=64)

Multicenter

Structured PICO

What is the incidence and nature of cardiac lesions in patients with disseminated intravascular coagulation?

Population

64 autopsy cases of disseminated intravascular coagulation, predominantly in older adults (mean age 76.3 years), evaluated for the presence and characteristics of fresh cardiac lesions.

Outcome

Incidence and types of fresh cardiac lesions (coronary thrombosis, myocardial necrosis, nonbacterial thrombotic endocarditis, mural thrombi, bleeding)surrogate

Disseminated intravascular coagulation is frequently associated with fresh cardiac lesions, including coronary thrombosis and myocardial necrosis, particularly in elderly patients.

Limitations

Limited number of histological preparations may have missed some instances of coronary thrombosis.
Differentiation between embolism and thrombosis was difficult, especially when distribution was diffuse.

Cite This Study

Sugiura et al. (1977) conducted an observational in Disseminated Intravascular Coagulation (DIC) (n=64). Disseminated intravascular coagulation was evaluated on Incidence of fresh cardiac lesions. Fresh cardiac lesions were found in 62.5% of autopsy cases with disseminated intravascular coagulation, including myocardial necrosis in 37.5% and coronary thrombosis in 20.3%.

synapsesocial.com/papers/6aa5847ca003dea1aa395806 https://doi.org/10.1536/ihj.18.57

Topics

Infective endocarditis

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Implication

Disseminated intravascular coagulation is frequently associated with fresh cardiac lesions, including coronary thrombosis and myocardial necrosis, particularly in elderly patients.

A Clinicopathological Study on Cardiac Lesions in 64 Cases of Disseminated Intravascular Coagulation

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Topics

A Clinicopathological Study on Cardiac Lesions in 64 Cases of Disseminated Intravascular Coagulation

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider