Key result
Synovial citrullinated antigens show similar prevalence in rheumatoid arthritis and controls without anti-CCP association.
Observational (n=80)
Absolute Event Rate: 43.3% vs 48%
Citrullinated antigens lack RA specificity; leaves open their role in anti-CCP–driven pathogenesis and requires prospective validation.
The presence of autoantibodies directed to citrulli-nated antigens in serum is highly specific for RA. The aim of this study was to compare anti-CCP concentrations in paired serum/SF samples of patients with RA and to investigate whether this is associated with the expression of citrullinated antigens in RA synovium and to study the nature of these antigens.
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Smeets et al. (2001) conducted an observational in Rheumatoid arthritis (n=80). Rheumatoid arthritis vs. Osteoarthritis, reactive arthritis, and other arthritides was evaluated on Expression of citrullinated antigens in synovium (staining with ScFv monoclonal antibody). Citrullinated antigens are present in the synovia of both rheumatoid arthritis and control patients with similar prevalence, and their expression is not associated with serum anti-CCP autoantibodies.
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