Reference Values for Doppler Indexes of Left Ventricular Diastolic Filling in the Elderly
Key result
Advancing age in healthy elderly subjects is linked to altered late LV filling peak velocity.
- P=0.005
- n=114
Population
114 rigorously selected healthy subjects aged 70 to 87 years from the Framingham Heart Study cohort.
Design
Cross-sectional
Authors
Discussion
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Implication
Supports age-adjusted LV diastolic norms in healthy elderly; leaves open prospective outcome validation before clinical adoption.
Study Design
Type
Observational (n=114)
Multicenter
No
Structured PICO
P
Population
114 rigorously selected healthy adults aged 70 to 87 years from the Framingham Heart Study evaluated to generate reference values for Doppler indexes of LV diastolic filling.
O
Outcome
Reference values for Doppler indexes of left ventricular diastolic fillingsurrogate
Main Result
p-value: p=0.005
This study establishes reference values for Doppler indexes of LV diastolic filling in healthy elderly subjects, demonstrating that an E/A ratio <1.0 is a normal finding in this population.
Cite This Study
Sagie et al. (1993) conducted an observational in Healthy elderly (n=114). Advancing age vs. Younger age groups was evaluated on Peak velocity of late filling (p=0.005). Advancing age in healthy elderly subjects was associated with a significant change in peak velocity of late left ventricular filling (56 vs 62 cm, P=0.005).