An Article Contributed to an Anniversary Volume in Honor of Doctor Joseph Hersey Pratt

Article1 June 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTTHE EFFECTS OF LARGE DOSES OF BENZEDRINE SULPHATE ON THE ALBINO RAT: FUNCTIONAL AND TISSUE CHANGES*WILLIAM E. EHRICH, M.D., E. B. KRUMBHAAR, M.D., Ph.D., F.A.C.P.WILLIAM E. EHRICH, M.D.Search for more papers by this author, E. B. KRUMBHAAR, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-12-1874 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the synthetic preparations of the epinephrine group, benzedrine (phenylisopropylamine) is in some respects more efficient than epinephrine and ephedrine, and also has additional therapeutic effects. As a sympathetic stimulant it produces mydriasis and piloerection (Alles1; Prinzmetal and Bloomberg2; Myerson, Loman and Dameshek3). It raises both blood and spinal fluid pressure, the rise being maintained for a longer period than after injection of the other two drugs (Alles1; Piness, Miller and Alles4; Hartung and Munch5; Tainter6; Myerson, Loman and Dameshek3). Like these drugs, it increases the number of erythrocytes and leukocytes in the blood, and to a lesser extent the...References1. ALLES GA: The comparative physiological actions of dl-B-phenylisopropylamines, Jr. Pharm. and Exper. Therap., 1933, xlvii, 339. Google Scholar2. PRINZMETALBLOOMBERG MW: The use of benzedrine for the treatment of narcolepsy, Jr. Am. Med. Assoc., 1935, cv, 2051. CrossrefGoogle Scholar3. MYERSONLOMANDAMESHEK AJW: Physiologic effects of benzedrine and its relationship to other drugs affecting the autonomic nervous system, Am. Jr. Med. Sci., 1936, cxcii, 560. CrossrefGoogle Scholar4. PINESSMILLERALLES GHGA: Clinical observations on phenylaminoethanol sulphate, Jr. Am. Med. Assoc., 1930, xciv, 790. CrossrefGoogle Scholar5. HARTUNGMUNCH WHJC: The amino alcohols. VI. The preparation and pharmacodynamic activity of four isomeric phenylpropylamines, Jr. Am. Chem. Soc., 1931, liii, 1875. CrossrefGoogle Scholar6. Cited by Myerson, Loman and Dameshek.3 Google Scholar7. MYERSONRITVO AM: Benzedrine sulfate and its value in spasm of the gastrointestinal tract, Jr. Am. Med. Assoc., 1936, cvii, 24. CrossrefGoogle Scholar8. DONALDSON HH: The rat, The Wistar Institute, Philadelphia, 1915. Google Scholar9. PETRI E: Pathologische Anatomie und Histologie der Vergiftungen, Henke und Lubarsch, Hand. d. spez. pathol. Anat. u. Hist., Vol. X, Julius Springer, Berlin, 1930. CrossrefGoogle Scholar10. CHEN KK: The acute toxicity of ephedrine, Jr. Pharm. and Exper. Therap., 1926, xxvii, 61; The effect of repeated administration of ephedrine, Ibid., p. 77. Google Scholar11. CORI CF: The influence of insulin and epinephrine on the fats in the animal body, The Harvey Lectures, 1927-28, xxiii, 76. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented in brief before the Section on General Medicine of the College of Physicians of Philadelphia, January 25, 1937, and the American Association of Pathologists and Bacteriologists, Chicago, March 25, 1937. Received for publication April 13, 1937.From the Department of Pathology, University of Pennsylvania.Aided by a grant from Smith, Kline & French, Inc. 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