All articles of this category The three chiral building blocks ethyl 4,5- O -isopropylidene-( E )-( S )-4, 5-dihydroxy-2-pentenoate [1,3-dioxolane derivative ( E )-( S )- 1a ], ( S )-5-hydroxy-4-pentanolide [( S )- 2a ], and ( S )-5-hydroxy-2-penten-4-olide [( S )- 3a ] are conveniently prepared from 1,2;5,6-di- O -isopropylidene-D-mannitol ( 4 ) via a glycol cleavage and Horner-Emmons reaction sequence.
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Takano et al. (1986) studied this question.