Key result
SystemCHANGE intervention linked to 97% medication adherence by matching timing to daily behaviors.
Why the study?
In kidney transplant recipients, non-adherence to immunosuppressive medications leads to rejection, impaired organ function, increased mortality, and higher healthcare costs.
Does the SystemCHANGE intervention improve medication adherence in a non-adherent adult kidney transplant recipient?
Case Report (n=1)
No
Does the SystemCHANGE intervention improve medication adherence in a non-adherent adult kidney transplant recipient?
The SystemCHANGE intervention resulted in a clinically meaningful 23% increase in medication adherence in a non-adherent kidney transplant recipient.
Answers are grounded in this paper and cite their sources.
May support habit-based adherence strategies in kidney transplant recipients; hypothesis-generating and requires randomized confirmation.
In kidney transplant recipients, non-adherence to immunosuppressive medications leads to rejection, which negatively affects the function of the transplanted organ and increases mortality rates and healthcare costs. The purpose of this paper is to report a case from the parent study which is designed to test the efficacy of the SystemCHANGETM intervention compared to an attention-control intervention on medication adherence at 6 and 12 months in non-adherent Turkish adult kidney transplant recipients. This is a case report from the Turkish parent study which mirrored the methods of the Medication Adherence Given Individual Change (MAGIC) studies conducted with adult kidney transplant recipients that have been previously published. This study reports a case study of an adult kidney transplant recipient with poor medication adherence enrolled in an innovative six-month SystemCHANGETM intervention. Medication adherence increased immediately and was sustained throughout the intervention and maintenance phases. The SystemCHANGETM intervention resulted in immediate and sustained improvements in medication adherence. The patient experienced a clinically meaningful increase in MA (23%) by improving the timing of doses by linking them to a regularly occurring behavior. This is the first case study conducted in different culture, and the second case study on this topic in the international literature. The SystemCHANGETM intervention was effective in increasing medication adherence and quality of life in this individual.
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Ordin et al. (2024) conducted a case report in Kidney transplant recipient with poor medication adherence (n=1). SystemCHANGE intervention vs. Baseline (screening phase) was evaluated on Medication adherence score. The SystemCHANGE intervention increased medication adherence from 62% at baseline to 97% at 6 months by linking medication timing to regularly occurring daily behaviors.
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