Key result
Diabetic rat aortae show attenuated contractile responses to endothelin-1, KCl, and CaCl2 but not noradrenaline.
Two weeks of STZ-induced diabetes in rats attenuates aortic contractile responses to ET-1, KCl, and CaCl2, but not noradrenaline, independent of the endothelium.
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Caution against clinical extrapolation from short-term rodent aortae; leaves open translational relevance to human diabetic vasculopathy.
Fulton et al. (1991) studied Streptozotocin-induced diabetes mellitus. Streptozotocin vs. Vehicle-treated control rats was evaluated on Maximum responses to ET-1, KCl, CaCl2, and noradrenaline. Aortae from rats with two-week streptozotocin-induced diabetes showed attenuated maximum responses to endothelin-1, KCl, and CaCl2, but not noradrenaline, compared to controls.
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