What question did this study set out to answer?

To evaluate evolving presurgical trial designs combining endocrine therapy with novel targeted agents and to establish Ki67 as a primary surrogate endpoint in estrogen receptor-positive breast cancer.

October 1, 2011JNCI MonographsOpen Access

Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer

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To evaluate evolving presurgical trial designs combining endocrine therapy with novel targeted agents and to establish Ki67 as a primary surrogate endpoint in estrogen receptor-positive breast cancer.
Review of window-of-opportunity studies and extended preoperative regimens (≥3 months) targeting endocrine resistance mechanisms.
The POETIC trial randomized (2:1) 4,000 estrogen receptor-positive patients to two weeks of presurgical treatment with a nonsteroidal aromatase inhibitor versus no presurgical therapy.
Assessment of Ki67 proliferation indices pre- and post-treatment as the primary intermediate biological endpoint.
Validation of Ki67 as a robust intermediate marker reflecting therapeutic benefit and long-term clinical outcome under endocrine suppression.
Establishment of short-term preoperative trial frameworks to analyze molecular determinants of response and acute resistance to estrogen deprivation.

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Implication

Randomized trial evaluates short-term presurgical aromatase inhibition in estrogen receptor-positive breast cancer, highlighting Ki67 as a biomarker for treatment response.

Cite This Study

Dowsett et al. (2011) studied this question.

synapsesocial.com/papers/6aa595f8c616a76b5feeca1d https://doi.org/10.1093/jncimonographs/lgr034

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Implication

Randomized trial evaluates short-term presurgical aromatase inhibition in estrogen receptor-positive breast cancer, highlighting Ki67 as a biomarker for treatment response.

Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer

Key Points

Discussion

Implication

Cite This Study

Endocrine Therapy, New Biologicals, and New Study Designs for Presurgical Studies in Breast Cancer

Key Points

Discussion

Implication

Cite This Study

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