The base resolution in the detection of single DNA strands with nanopores can be improved by attaching chemical tags to individual bases. Different chemical tags give rise to characteristic current signatures when a DNA molecule passes through a nanopore (see picture). This sequence-specific sensing with modified DNA is independent of pore engineering and can potentially be applied to analyze nucleic acids with a wide range of solid-state nanopores.
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Stefan Howorka (2008) studied this question.
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