Key result
Energy drinks show no effect on QTc, heart rate, or systolic BP versus coffee or water.
Why the study?
Does acute consumption of energy drinks affect heart rate, blood pressure, and QTc interval compared to coffee or water?
RCT (n=15)
Double-blind
Randomized
Does acute consumption of energy drinks affect heart rate, blood pressure, and QTc interval compared to coffee or water?
p-value: p=>0.05
Acute consumption of energy drinks does not negatively affect cardiac QTc interval, heart rate, or systolic blood pressure compared to coffee or water.
Reassures on acute energy drink safety for QTc and hemodynamics; extends RCT evidence of neutrality versus coffee or water.
The goal of this study was to investigate the impact of energy drinks on haemodynamic and cardiac physiology. Comparisons were made to coffee as well as water consumption. In Protocol #1 the caffeine content was normalized to body weight to represent a controlled environment. Heart rate, blood pressure and cardiac QTc interval were assessed in 15 participants, on 4 days, prior to and for 6·5 h postconsumption of (i) energy drink (2 mg caffeine per kg body weight; low dose), (ii) energy drink (3 mg caffeine per kg body weight; medium dose), (iii) coffee (2 mg caffeine per kg body weight) and (iv) 250 ml water. In Protocol #2, the beverages were consumed in volumes that they are purchased to represent real-life conditions. The aforementioned measurements were repeated in 15 participants following (i) 1 16 oz can of energy drink (16 oz Monster), (ii) 1 24 oz can of energy drink (24 oz Monster), (iii) 1 packet of Keurig K-Cup Starbucks coffee (coffee) and (iv) 250 ml water. The order of the beverages was performed in a randomized double-blinded fashion. For both protocols, QTc interval, heart rate and systolic blood pressure were unchanged in any condition (P>0·05). Diastolic blood pressure and mean blood pressure were slightly elevated in Protocol #1 (P<0·05, main effect of time) with no difference between beverages (P<0·05, interaction of beverage × time); however, they were unaffected in Protocol #2 (P>0·05). These findings suggest that acute consumption of these commonly consumed beverages has no negative effect on cardiac QTc interval.
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Brothers et al. (2016) reported an RCT. Energy drink vs. Coffee and water was evaluated on QTc interval, heart rate and systolic blood pressure (p=>0.05). Acute consumption of energy drinks, compared to coffee or water, had no significant effect on cardiac QTc interval, heart rate, or systolic blood pressure (P>0.05).
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