Key result
Case report links esophageal chemoradiotherapy to fulminant postirradiation sarcoma after a 2-month latent period.
Case Report (n=1)
FDG PET may be useful in distinguishing post-therapeutic changes from tumor recurrence in patients developing rapid postirradiation sarcomas.
Alerts clinicians to sarcomas arising within months of chemoradiation; leaves open the minimal latency for radiation-induced histiocytoma.
A 49-year-old man had a secondary primary esophageal squamous cell carcinoma that was treated with neoadjuvant concurrent chemoradiotherapy (CCRT). An unexpected fulminant postirradiation malignant fibrous histiocytoma developed in the irradiation field 2 months after the CCRT. After esophagectomy and adjuvant radiation therapy, widespread disease still occurred in 2 months and he died of tumor bleeding 2 months later. The serial diagnostic images were compared and revealed that fluoro-deoxy-glucose positron emission tomography (FDG PET) was more useful in distinguishing post-therapeutic change and tumor recurrence in the region after surgical and radiation therapy. This report is of a postirradiation sarcoma with a very short latent period.
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Hsieh et al. (2009) conducted a case report in Esophageal squamous cell carcinoma and postirradiation soft tissue sarcoma (n=1). Neoadjuvant concurrent chemoradiotherapy was evaluated on Development of postirradiation sarcoma. A 49-year-old man developed a fulminant postirradiation malignant fibrous histiocytoma with a very short latent period of 2 months after concurrent chemoradiotherapy for esophageal cancer.
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