Key result
Interferon-induced cellular resistance depends on RNA and protein synthesis despite lacking direct antiviral protein evidence.
This review summarizes the mechanisms by which interferon induces an antiviral state, focusing on the roles of cellular RNA and protein synthesis.
Interferon antiviral resistance requires host RNA and protein synthesis; leaves open whether a specific induced protein or ribosomal changes mediate protection.
The development of resistance in response to interferon depends on cellular RNA synthesis and probably also on cellular protein synthesis. The evidence for these requirements is reviewed, as well as the proposal that this evidence indicates the existence of a specific response of the cell to interferon, involving the induced synthesis of an antiviral protein. Direct evidence for such an interpretation has not been obtained, and alternative explanations are discussed which do not require quantitative or qualitative differences in the RNA and protein made in cells exposed to interferon. The possible role of the ribosome in the antiviral action of interferon is also discussed.
No takes yet. Share an insight, caveat, or question.
Sonnabend et al. (1970) conducted a review in Antiviral state / Interferon response. Interferon was evaluated. The development of cellular resistance in response to interferon depends on cellular RNA and protein synthesis, though direct evidence for an induced antiviral protein remains lacking.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: