24-Hour Urinary Creatinine Excretion is not Altered in Human Pregnancy

Objective: To assess whether creatinine excretion alters in human pregnancy.Methods: Longitudinal study of 24-h urinary excretion of creatinine during human pregnancy.Main Outcome Measures: Relative creatinine excretion as pregnancy advanced.Results: Twenty-four-hour creatinine excretion remained relatively constant as pregnancy advanced.Conclusions: Creatinine excretion can be used with confidence during pregnancy for estimation of completeness of collection in examination of 24-h excretion of other metabolites.We have shown that 24-h creatinine excretion is relatively constant during human pregnancy. Creatinine excretion can therefore be used with confidence during pregnancy for estimation of completeness of collection in examination of 24-h excretion of other metabolites.