Key result
Adding dexamethasone to bupivacaine for supraclavicular block speeds onset and prolongs sensory and motor blockade.
Why the study?
Bupivacaine is frequently used for brachial plexus block in upper limb surgeries but has drawbacks of delayed onset and patchy analgesia.
Does the addition of dexamethasone to bupivacaine improve the onset and duration of sensory and motor blockade in patients undergoing upper limb surgeries?
RCT (n=60)
Single-blind
Randomized
Does the addition of dexamethasone to bupivacaine improve the onset and duration of sensory and motor blockade in patients undergoing upper limb surgeries?
The addition of dexamethasone to bupivacaine for supraclavicular brachial plexus block significantly speeds the onset and prolongs the duration of sensory and motor blockade.
May accelerate onset and prolong bupivacaine block for upper-limb surgery; leaves open optimal dosing, safety, and confirmation in larger RCTs.
Aim:To study the onset and duration of sensory and motor blockade Introduction: Brachial plexus block provides a useful alternative to general anaesthesia for upper limb surgeries. Bupivacaine is one of the most frequently used local anaesthetic which has a longer duration of action of 3 to 8 hours but has drawbacks of delayed onset and patchy analgesia. Dexamethasone is a very potent glucocorticoid with very good anti-inammatory and analgesic activity. Materials and methods: A prospective, randomised single-blinded study was undertaken in patients posted for upper limb surgeries under the supraclavicular block. 60 patients with ASA class I and II were randomly grouped into two groups. Group I received 30ml bupivacaine 0.5% and Group II received a combination of 28ml bupivacaine 0.5% and 2ml dexamethasone 8mg. 30ml solution is used for a single shot blockade of supraclavicular brachial plexus. Results: Group II patients had a faster onset of action and prolonged duration of action. Discussion: The addition of dexamethasone 8mg to bupivacaine 0.5% speeds the onset of sensory and motor blockade also prolongs the duration thus provides better analgesia and reduces the requirements of rescue analgesics. Conclusion:Acombination of bupivacaine 0.5% and dexamethasone 8mg has a signicantly faster onset and prolonged duration of action.
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Mounica et al. (2021) conducted an RCT in Upper limb surgeries requiring supraclavicular block (n=60). Bupivacaine and dexamethasone combination vs. 30ml bupivacaine 0.5% was evaluated on Onset and duration of sensory and motor blockade. The addition of dexamethasone 8mg to bupivacaine 0.5% for supraclavicular block significantly speeds the onset and prolongs the duration of sensory and motor blockade.
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