Key result
Acute lung injury is linked to ~473% higher risk of delayed extubation after ATAAD surgery.
Why the study?
Risk factors for prolonged mechanical ventilation after acute type A aortic dissection surgery needed to be identified.
Observational (n=466)
No
Odds Ratio: 5.725 (95% CI 2.777–12.148)
p-value: p=<0.001
Age, postoperative serum creatinine, and acute lung injury are significant risk factors for prolonged mechanical ventilation after acute type A aortic dissection surgery.
May aid perioperative risk stratification after ATAAD surgery; leaves open whether targeting these factors shortens ventilation time.
Objective To identify the risk factors of prolonged mechanical ventilation after acute type A aortic dissection (ATAAD) surgery. Methods 466 patients undergoing ATAAD surgery from 2016.01 to 2021.01were studied retrospectively. Risk factors of delayed extubation (>48 h of ventilation) were identified using univariate and multivariate logistic regression. LASSO regression was used for variable selection. The ICU stay, hospital stay, complications, and 30-day mortality were analyzed. Results Among the patients, 72% experienced delayed extubation. Risk factors included age (OR 1.042, 95% CI 1.005–1.083, P = 0.031), postoperative serum creatinine (Scr, OR 1.006, 95% CI 1.003–1.010, P < 0.001), and acute lung injury (ALI, OR 5.725, 95% CI 2.777–12.148, P < 0.001). Delayed extubation was associated with increased ICU stays, hospital stays, and complications, including MODS and higher mortality. Conclusions Age, postoperative serum creatinine, and acute lung injury are significant risk factors for prolonged ventilation. Early identification and management of these factors may improve postoperative outcomes.
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Chen et al. (2025) conducted an observational in Acute type A aortic dissection (ATAAD) (n=466). Acute lung injury, postoperative serum creatinine, and age vs. Absence of risk factors or lower values was evaluated on Delayed extubation (>48 h of mechanical ventilation) (OR 5.725, 95% CI 2.777-12.148, p=<0.001). Acute lung injury (OR 5.725), postoperative serum creatinine (OR 1.006), and older age (OR 1.042) were identified as significant independent risk factors for delayed extubation after ATAAD surgery.
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