Key result
DEV UL14 gene codon usage exhibits high diversity toward C- and G-ending synonymous codons.
The DEV UL14 gene exhibits codon usage bias towards C and G at the third position, making the E. coli expression system suitable for its heterologous expression.
May support E. coli for DEV UL14 expression; leaves open functional impacts of codon bias.
The codon usage of DEV UL14 gene was analyzed by using CAI, CHIPS and CUSP program of EMBOSS. The results showed that codon usage bias in the DEV UL14 gene was a high level of diversity in codon usage bias towards the synonymous with C and G at the third codon position existed for coding the Glu, Gly, Asn and Tyr amino acids. The cluster analysis demonstrated that the codon usage bias of DEV UL14 gene has a very close relationship with its gene function and gene type. In addition, the E.coli expression system is more suitable for heterologous expression of the DEV UL14 gene.
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Li et al. (2012) studied Duck Enteritis Virus. Codon usage analysis was evaluated on Codon usage bias. Codon usage bias in the DEV UL14 gene showed a high level of diversity towards synonymous codons with C and G at the third position for coding Glu, Gly, Asn, and Tyr.
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