January 1, 1989Hypertension
Atrial natriuretic factor inhibits isoproterenol- and furosemide-stimulated renin release in humans.
Key result
Atrial natriuretic factor abolishes isoproterenol-induced rises in plasma renin activity and attenuates rises after furosemide.
- P=0.003 and 0.048
- n=7
Why the study?
Does atrial natriuretic factor inhibit isoproterenol- and furosemide-stimulated renin release in healthy volunteers?
Population
7 salt-replete healthy volunteers
Comparison
Atrial natriuretic factor background infusion vs 5% D-glucose background infusion (placebo day)
Design
Other
Authors
Discussion
Loading...
Member takes
Implication
ANF may inhibit stimulated renin release in healthy volunteers; leaves open its role in hypertension or heart failure management.
Study Design
Type
RCT (n=7)
Structured PICO
Does atrial natriuretic factor inhibit isoproterenol- and furosemide-stimulated renin release in healthy volunteers?
P
Population
7 salt-replete healthy volunteers.
I
Intervention
Atrial natriuretic factor (0.025 microgram/kg/min) background infusion
C
Comparator
5% D-glucose background infusion (placebo day)
O
Outcome
Rise in plasma renin activity caused by isoproterenol (0.02 microgram/kg/min) or furosemide (5 mg i.v. bolus)surrogate
Main Result
p-value: p=0.003 and 0.048
A pharmacological dose of atrial natriuretic factor nonspecifically inhibits stimulated renin release in humans.
Cite This Study
McMurray et al. (1989) conducted an RCT in Healthy volunteers (n=7). Atrial natriuretic factor vs. 5% D-glucose (placebo) was evaluated on Rise in plasma renin activity (p=0.003 and 0.048). Atrial natriuretic factor abolished the rise in plasma renin activity caused by isoproterenol (p=0.003) and attenuated the rise after furosemide (p=0.048).