Why the study?
Does atrial natriuretic factor modulate proximal glomerulotubular balance in anesthetized rats, and is this effect dependent on interference with angiotensin II?
Population
Anesthetized rats
Comparison
Prolonged low dose infusion of atrial… vs Control state (before interventions)
Design
Preclinical
Authors
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ANF glomerular effects persist during ACE inhibition in rats; leaves open translation to human hypertension management.
Does atrial natriuretic factor modulate proximal glomerulotubular balance in anesthetized rats, and is this effect dependent on interference with angiotensin II?
Atrial natriuretic factor possesses a glomerular action that persists during converting enzyme inhibition and is additive to the removal of angiotensin II.
Zhuo et al. (1989) studied this question.
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