What does this research mean for the field?

Enalapril attenuates the natriuretic and renal hemodynamic effects of atrial natriuretic factor in humans, indicating that these effects depend on renal angiotensin II and are influenced by blood pressure reduction. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand how enalapril affects sodium excretion in response to atrial natriuretic factor in healthy individuals.

February 1, 1988Hypertension

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

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Why the study?

Does enalapril attenuate the natriuresis induced by atrial natriuretic factor in healthy humans?

Population

8 healthy humans consuming a 100 mmol sodium diet

Comparison

Enalapril 20 mg b.i.d. for 4 days prior to… vs Atrial natriuretic factor administration without…

Design

Other

Follow-up

4 days

Authors

SGSandrine GaillardGoethe University Frankfurt HKH A KoomansUtrecht University EME. J. Dorhout MeesRijksmuseum

Discussion

Member takes

Implication

Supports angiotensin II mediation of ANF effects; extends mechanistic understanding but leaves open any clinical implications in hypertension.

Key Points

This research aims to understand how enalapril affects sodium excretion in response to atrial natriuretic factor in healthy individuals.
Examined eight healthy humans on a controlled sodium diet.
Administered atrial natriuretic factor before and after enalapril treatment over four days.
Measured changes in sodium excretion and renal parameters.
Without enalapril, sodium excretion increased from 127 to 437 mumol/min after ANF.
With enalapril, sodium excretion rose less, from 117 to 242 mumol/min after ANF.
A significant reduction in glomerular filtration rate and other renal clearances was noted with enalapril.

Structured PICO

Does enalapril attenuate the natriuresis induced by atrial natriuretic factor in healthy humans?

Population

8 healthy humans consuming a 100 mmol sodium diet

Intervention

Enalapril 20 mg b.i.d. for 4 days prior to atrial natriuretic factor (human ANF-[99-126], 100-micrograms bolus i.v. injection)

Comparator

Atrial natriuretic factor administration without enalapril

Outcome

Sodium excretion in the first 20 minutes after ANF administrationsurrogate

Enalapril attenuates the natriuretic and renal hemodynamic effects of atrial natriuretic factor in healthy humans, suggesting these effects depend on renal angiotensin II.

Cite This Study

Gaillard et al. (1988) studied this question.

synapsesocial.com/papers/6a1bd1876f692abb725eea46 https://doi.org/10.1161/01.hyp.11.2.160

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Implication

Supports angiotensin II mediation of ANF effects; extends mechanistic understanding but leaves open any clinical implications in hypertension.

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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