Key Points
- This research aims to understand how enalapril affects sodium excretion in response to atrial natriuretic factor in healthy individuals.
- Examined eight healthy humans on a controlled sodium diet.
- Administered atrial natriuretic factor before and after enalapril treatment over four days.
- Measured changes in sodium excretion and renal parameters.
- Without enalapril, sodium excretion increased from 127 to 437 mumol/min after ANF.
- With enalapril, sodium excretion rose less, from 117 to 242 mumol/min after ANF.
- A significant reduction in glomerular filtration rate and other renal clearances was noted with enalapril.
Structured PICO
Does enalapril attenuate the natriuresis induced by atrial natriuretic factor in healthy humans?
PPopulation8 healthy humans consuming a 100 mmol sodium diet
IInterventionEnalapril 20 mg b.i.d. for 4 days prior to atrial natriuretic factor (human ANF-[99-126], 100-micrograms bolus i.v. injection)
CComparatorAtrial natriuretic factor administration without enalapril
OOutcomeSodium excretion in the first 20 minutes after ANF administrationsurrogate
Enalapril attenuates the natriuretic and renal hemodynamic effects of atrial natriuretic factor in healthy humans, suggesting these effects depend on renal angiotensin II.