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We measured reticulocyte counts and the middle fluorescence ratio plus high fluorescence ratio (MFR + HFR), a measurement of reticulocyte maturity, using a Sysmex R-1000 Automated Reticulocyte Analyzer on 32 allogeneic and 8 autologous marrow transplant patients for 44 days posttransplant. We compared instrumentgenerated data with visual reticulocyte counts and white blood cell (WBC) counts. The MFR + HFR yielded a measurable increase from baseline at 13.31 days, compared to 14.82 days for WBC count, 16.21 days for instrument-generated reticulocyte count, and 16.59 days for visual reticulocyte count. Instrument reticulocyte count precision improved upon visual count precision by five to tenfold. The MFR + HFR may be a sensitive measurement of regeneration.
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Batjer et al. (1994) studied this question.
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