Alterations in lncRNAs H19 and TUG1 expression and their correlation with hemodynamics in myocardial infarction

Aim.This study aimed to investigate the changes in hemodynamic parameters and expression of lncRNAs H19 and TUG1 in a rat model of myocardial infarction (MI).Methods.The effects of MI (ligating the LAD during 4 weeks) on the hemodynamic parameters were evaluated using a specific recording catheter.Additionally, we assessed the changes in myocardial and plasma levels of lncRNAs H19 and TUG1 using quantitative PCR.Pearson's correlation coefficient analysis was employed to understand the relationship between the lncRNAs expression and hemodynamic para meters.Results.Our study revealed significant alterations in several hemodynamic parameters post-MI.The expression levels of H19 significantly decreased, while TUG1 increased in the myocardium and blood plasma of rats following MI.A strong correlation was identified between these lncRNAs and several hemodynamic parameters.Conclusions.The data suggest that H19 and TUG1 are potentially important regulators of cardiac function post-MI, with their altered expression levels being associated with significant changes in key hemodynamic parameters.These findings underscore the importance of lncR-NAs in the cardiac response to MI and pave the way for future studies to further elucidate their precise role and potential as therapeutic targets or biomarkers in heart disease.