Key result
COVID-19 vaccination linked to short-term HRV changes and rapid recovery within 3 days.
Why the study?
Establishing evidence-based safety information was needed to assess the potential impact of COVID-19 vaccinations on human heart rate variability parameters.
Does COVID-19 vaccination impact heart rate variability parameters in vaccinated individuals?
Systematic Review
Does COVID-19 vaccination impact heart rate variability parameters in vaccinated individuals?
COVID-19 vaccination is associated with transient, short-term changes in heart rate variability that rapidly recover within 3 days.
Reassures on transient post-vaccination HRV shifts; confirms rapid recovery in Level 1 evidence.
Establishing and disseminating evidence-based safety information could potentially facilitate beneficial choices in coronavirus disease (COVID-19) vaccinations. This systematic review investigated the potential impact of COVID-19 vaccinations on human heart rate variability (HRV) parameters through comprehensive searches of four electronic medical databases. Five observational studies reporting HRV parameters of individuals vaccinated against COVID-19 and published up to 29 July 2022 were included in this review. Among them, four studies reported the square root of the mean squared differences of successive NN intervals (RMSSD) as their outcome, and the remaining study reported an HRV-based stress indicator. These studies reported short-term changes and rapid recovery in HRV parameters within up to 3 days after COVID-19 vaccination. Some studies showed that the impact of COVID-19 vaccinations on RMSSD was greater in women than men, and in the younger group than in the older group. The methodological quality of the included studies was not optimal; the review revealed short-term changes in HRV parameters, particularly RMSSD, following COVID-19 vaccination. However, as the included studies did not report important parameters besides RMSSD, the limitation exists that the postvaccination long-term HRV stability was not reported.
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Kwon et al. (2022) conducted a systematic review in COVID-19 vaccination. COVID-19 vaccination was evaluated on Heart rate variability (HRV) parameters, particularly RMSSD. COVID-19 vaccination was associated with short-term changes and rapid recovery in heart rate variability parameters, particularly RMSSD, within up to 3 days post-vaccination.
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