Key result
Extensive biatrial linear ablation plus PVI restores sinus rhythm in a long-standing persistent AF case.
Why the study?
Catheter ablation endpoints for long-standing persistent AF are not yet clearly defined, with different ablative strategies offered to patients.
Case Report (n=1)
Describes a standardized ablation strategy for long-standing persistent atrial fibrillation utilizing biatrial linear ablation and isolation of the pulmonary veins, superior vena cava, and left atrial posterior wall.
May support individualized ablation in refractory long-standing persistent AF; leaves open efficacy and safety in prospective trials.
Catheter ablation of long-standing persistent atrial fibrillation is not yet clearly defined with respect to endpoints, and different ablative strategies are offered to patients. Presented here is an approach aiming at biatrial debulking in the form of extensive linear ablation, specifically targeting areas of low-voltage complex fractionated electrograms, in addition to pulmonary vein isolation. Its main advantage is that it is not dependent on operator/system variability, since the strategy of isolating the pulmonary veins, superior vena cava and left atrial posterior wall together with achievement of bidirectional block during linear ablation provides objective endpoints that can consistently be reproduced.
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Brunelli et al. (2020) conducted a case report in Long-standing persistent atrial fibrillation (n=1). Left and right atrial linear ablation in addition to pulmonary vein isolation was evaluated on Freedom from atrial fibrillation. Extensive biatrial linear ablation targeting low-voltage complex fractionated electrograms, in addition to pulmonary vein isolation, successfully restored sinus rhythm in a patient with long-standing persistent atrial fibrillation.
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