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July 1, 2008Annals of Surgery

Schizophrenia and major depression are linked to higher postoperative complication rates including death and delirium.

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Why the study?

Does serious mental illness increase the risk of perioperative complications in patients undergoing surgery?

Population

Patients diagnosed with serious mental illness undergoing surgery

Comparison

Surgery vs Patients without mental illness

Design

Systematic_review

Key result

Patients with schizophrenia (n=466 vs 338,257 controls in one study) and major depression may experience higher rates of postoperative complications, including death, confusion, and delirium.

Authors

LCLaurel A. CopelandJZJohn E. ZeberMPMary Jo Pugh

Discussion

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Overview

May warrant enhanced perioperative monitoring in serious mental illness; leaves open optimal strategies pending prospective trials.

Study Design

Type

Systematic Review

Structured PICO

Does serious mental illness increase the risk of perioperative complications in patients undergoing surgery?

P
Population
Systematic review of 12 studies evaluating perioperative medical, surgical, or psychiatric complications in patients with serious mental illness.
E
Exposure
Surgery
C
Comparator
Patients without mental illness
O
Outcome
Perioperative medical, surgical, or psychiatric complicationssafety

Patients with serious mental illness appear to be at higher risk for postoperative complications and delirium, highlighting the need for better perioperative management and further research.

Limitations

  • Few studies of perioperative outcomes in patients with serious mental illness
  • Most studies had fewer than 100 patients
  • No studies identified for patients with bipolar or posttraumatic stress disorder
  • Few studies available
  • Small sample sizes in most studies (9 of 10 schizophrenia studies had fewer than 100 patients)

Cite This Study

Copeland et al. (2008) conducted a systematic review in Serious mental illness undergoing surgery. Serious mental illness vs. Patients without mental illness was evaluated on Perioperative medical, surgical, or psychiatric complications. Patients with schizophrenia (n=466 vs 338,257 controls in one study) and major depression may experience higher rates of postoperative complications, including death, confusion, and delirium.

synapsesocial.com/papers/6aa5ef0b22b0548423396577https://doi.org/10.1097/sla.0b013e3181724f25
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