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Immunotherapy is now a pillar of cancer care, and natural killer (NK) cells are emerging as a key tool in its armamentarium. The feasibility, safety, and efficacy of delivering allogeneic NK cells is established1; however, few studies have interrogated how the functional diversity naturally present in NK cell populations might be leveraged for precise cancer control. In solid tumors particularly, where extensive microenvironmental diversity and tumor variability is present, the multifaceted ways in which NK cells recognize targets may enable continued and comprehensive targeting.
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Lee et al. (2026) studied this question.