Key result
Combined intra-LV and interventricular mechanical dyssynchrony is linked to pronounced LV remodeling and more cardiac events.
Why the study?
Differences and prognoses in CHF patients with left heart dysfunction and remodeling across different combinations of intra-LV and inter-V mechanical dyssynchrony or synchrony remained unclear.
Does ultrasound-quantified cardiac mechanical dyssynchrony associate with left heart function, remodeling, and cardiac events in patients with chronic heart failure?
Cohort
Does ultrasound-quantified cardiac mechanical dyssynchrony associate with left heart function, remodeling, and cardiac events in patients with chronic heart failure?
Intra-LV dyssynchrony is a stronger marker of LV dysfunction and remodeling than interventricular delay in CHF patients, and combined dyssynchrony predicts worse clinical outcomes.
Should not yet change practice in chronic HF; leaves open whether dyssynchrony-targeted interventions improve remodeling or outcomes.
Background: Ultrasound can be used to quantitatively assess cardiac mechanical dyssynchrony. The differences between and prognoses of chronic heart failure (CHF) patients with left heart dysfunction and remodeling for different combinations of intra-left ventricular (intra-LV) and interventricular (inter-V) mechanical dyssynchrony or synchrony remain unclear. This study sought to assess the relationships among intra-LV dyssynchrony, inter-V dyssynchrony, and left heart function and remodeling in CHF patients. Methods: ) and the interventricular mechanical delay (IVMD). All the patients underwent speckle-tracking echocardiography (STE) to assess LV and left atrial (LA) function, and the QRS width and echocardiographic findings were recorded. All patients were followed up for any cardiac events from the date of enrollment. A multivariable analysis was performed, and the Kaplan-Meier method was used to assess cardiac events. Results: 0.05). Conclusions: Compared with IVMD, intra-LV dyssynchrony is more strongly associated with LV dysfunction and remodeling in CHF patients, and LA dysfunction is predominantly contingent upon/is largely dependent on LV dysfunction. When both intra-LV and inter-V dyssynchrony are present, the extent of the LV volumetric increase and electrical remodeling is the most pronounced. This patient group had a higher incidence of cardiac events during follow up and a greater likelihood of receiving CRT.
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Su et al. (2025) conducted a cohort in Chronic heart failure (CHF). Intra-left ventricular (intra-LV) and interventricular (inter-V) mechanical dyssynchrony vs. Interventricular mechanical delay (IVMD) or synchrony was evaluated on Cardiac events. Combined intra-left ventricular and interventricular mechanical dyssynchrony was associated with the most pronounced left ventricular remodeling and a higher incidence of cardiac events.
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