Key result
Familial short stature in GH-treated children is linked to better parentally adjusted final height.
Why the study?
Does parental height affect final height outcomes after growth hormone administration in children with isolated growth hormone deficiency?
Cohort (n=49)
Does parental height affect final height outcomes after growth hormone administration in children with isolated growth hormone deficiency?
In children with isolated growth hormone deficiency, those with short parents attain better parentally adjusted final height than expected compared to those with normal height parents, partly due to differences in bone age advancement.
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Parental height should inform adjusted height expectations after GH in IGHD children; leaves open whether it modifies treatment response.
Şıklar et al. (2009) conducted a cohort in Isolated Growth Hormone Deficiency (n=49). Familial short stature vs. Normal familial stature was evaluated on Final height and parentally adjusted final height. Familial short stature in isolated growth hormone deficient children treated with GH was associated with similar final height but significantly better parentally adjusted final height compared to normal familial stature.
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