Key result
Monotherapy treats ~52% of hypertensive patients, most frequently with calcium channel blockers.
Why the study?
Hypertension contributes to the development of major cardiovascular diseases, prompting an evaluation of antihypertensive drug utilization patterns at a tertiary care hospital relative to standard guidelines.
Cross-Sectional (n=120)
No
In this tertiary care setting, antihypertensive monotherapy was the most common regimen, though a significant proportion of patients remained with elevated blood pressure.
Monotherapy predominates despite frequent uncontrolled BP; leaves open whether combinations improve control in observational data.
Introduction: Hypertension represents a major health problem primarily because of its role in contributing to the initiation and progression of major cardiovascular diseases. This cross-sectional observational study aims at analysing the utilization pattern of antihypertensives used for the treatment of hypertension at a tertiary care hospital in perspective of standard treatment guidelines. Materials and Methods: This is a prospective, cross sectional and observational study carried out in the outpatient of Department of General Medicine of NC Medical College and Hospital. All patients with proven hypertension and put on antihypertensive medications were recruited from the Department of Medicine. The total duration of the study was 1 year i.e. December 2019 to November 2020. Results: In our study, the mean systolic blood pressure (mean±S.D) of the patients was 154.34±9.43 and the median was 153. Test of proportion showed most of the patients 53 (44.1%) were significantly higher systolic blood pressure ranging from 160-179 mmHg. The mean diastolic blood pressure (mean±S.D) of the patients was 98.32±8.43. Test of proportion showed most of the patients 51 (42.5%) were significantly higher diastolic blood pressure ranging from 100-119 mmHg. Test of proportion showed most of the patients 62 (51.6%) were on Mono therapy significantly higher than dual therapy, triple therapy and poly therapy, 34 (26.6%), 13 (10.8%), 11 (9.1%) respectively. Causality assessment of ADRs was done using WHOUMC scale which categorizes ADRs as “certain”, “probable”, “possible” and “unlikely”. Table 8 shows that type of reactions and their percentage are as certain (9.6%), Probable/ Likely (67.7%), Possible (19.3%), and Unlikely (3.2%). Conclusions: In this study usage of anti-hypertensive drugs were prescribed rationally in tertiary care hospital. The study emphasizes that need for effective continuing medical education and also preventive measures in hypertensive individuals.
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Setiya et al. (2020) conducted a cross-sectional in Hypertension (n=120). Antihypertensive drugs was evaluated on Proportion of patients on monotherapy. Most hypertensive patients (51.6%) were managed with monotherapy, with calcium channel blockers being the most frequently prescribed class.
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