Effect of Resection of Gastrin Releasing Regions on Acid Response to Sham Feeding and Insulin Hypoglycemia in Pavlov Pouch Dogs

In 9 Pavlov pouch dogs, in which antrum‐duodenum had previously been excluded from gastrointestinal continuity, the antrum was resected. Additional resections of the duodenal bulb and distal 3–4 cm of corpus were performed in 5 of the dogs. Following these resections the acid response to sham feeding was reduced to extremely low values in all animals. The post‐resection sham feeding response was markedly increased upon injection of subthreshold amounts of gastrin suggesting that physiological vagal excitation of the HC1 glands by sham feeding requires the presence of gastrin to produce significant acid secretion in these preparations. In contrast a substantial post‐resection acid response to 0.4–0.6 I.U. of insulin per kg b.w. was still obtained in 6 of 7 dogs. The present results show that the excitations of the HC1 glands by sham feeding and relatively high doses of insulin are incommensurable, and suggest that vagal activation by these doses of insulin produces acid secretion independent of the gastrin mechanism.