Key result
Kv1.3 and Kv1.5 expression linked to tumor malignancy in human skeletal muscle sarcomas.
Observational
Should not alter sarcoma management; leaves open whether Kv1.3/1.5 blockade modifies malignancy.
Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.
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Bielańska et al. (2012) conducted an observational in Human skeletal muscle sarcomas (alveolar and embryonal rhabdomyosarcoma). Kv1.3 and Kv1.5 expression vs. Healthy adult and embryonic muscle samples was evaluated on Expression levels of Kv1.3 and Kv1.5 and correlation with tumor malignancy. Kv1.3 and Kv1.5 expression correlated with tumor malignancy in human skeletal muscle sarcomas, with Kv1.5 expression being notable in aggressive alveolar rhabdomyosarcoma.
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