Why the study?
Does domperidone administration increase the risk of long QT syndrome, ventricular arrhythmias, and sudden cardiac death?
Population
Literature review of 22 papers evaluating domperidone exposure.
Design
Review
Key result
Domperidone exposure was associated with an increased risk of sudden cardiac death (OR 3.8; 95% CI 1.5-9.7) based on a case-control study identified in the literature review.
Authors
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May warrant domperidone caution in cardiac-risk patients; leaves open causal confirmation in prospective trials.
Does domperidone administration increase the risk of long QT syndrome, ventricular arrhythmias, and sudden cardiac death?
Odds Ratio: 3.8 (95% CI 1.5–9.7)
Domperidone is associated with a risk of QT prolongation and sudden cardiac death, prompting caution especially when co-administered with CYP3A4 inhibitors or other QT-prolonging drugs.
Rossi et al. (2010) conducted a review in Long QT syndrome and ventricular arrhythmias. Domperidone was evaluated on Sudden Cardiac Death (SCD) (OR 3.8, 95% CI 1.5-9.7). Domperidone exposure was associated with an increased risk of sudden cardiac death (OR 3.8; 95% CI 1.5-9.7) based on a case-control study identified in the literature review.