August 1, 2011Acta cardiologica. Supplementum

Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death

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Why the study?

Does domperidone induce cardiac repolarization disturbances and arrhythmias in a preclinical model?

Population

Langendorff perfused rabbit hearts

Design

Preclinical

Authors

LHLuc M. HondeghemFlanders Marine Institute

Discussion

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Implication

Domperidone shows low safety margin for proarrhythmia in animal tissue; leaves open clinical translation and does not yet support practice changes.

Structured PICO

Does domperidone induce cardiac repolarization disturbances and arrhythmias in a preclinical model?

Population

Langendorff perfused rabbit hearts

Intervention

Domperidone (tested at concentrations starting at 30 nM and 100 nM)

Outcome

Liability of cardiac repolarization disturbances (triangulation, reverse use dependence, instability and dispersion or TRIaD) and induction of arrhythmiassafety

Domperidone has a dangerously low safety ratio for inducing proarrhythmic repolarization disturbances, providing a mechanistic explanation for clinical reports of sudden cardiac death and challenging its over-the-counter availability.

Cite This Study

Luc M. Hondeghem (2011) studied this question.

synapsesocial.com/papers/6a73b1d4d3d4e530dbfb791e https://doi.org/10.1080/ac.66.4.2126588

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Implication

Domperidone shows low safety margin for proarrhythmia in animal tissue; leaves open clinical translation and does not yet support practice changes.

Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Low safety index of domperidone: mechanism for increased odds ratio for sudden cardiac death

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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