Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease
Why the study?
Does domperidone use increase ventricular tachyarrhythmia and sudden cardiac death in newly-diagnosed patients with Parkinson's disease?
Population
214,962 newly-diagnosed patients with Parkinson's disease (PD)
Comparison
Domperidone use vs No use of domperidone
Design
Cohort
Follow-up
886,581 person-years
Authors
Discussion
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Member takes
Implication
May warrant caution with domperidone in cardiovascular disease; leaves open confirmation in Parkinson's disease cohorts.
Structured PICO
Does domperidone use increase ventricular tachyarrhythmia and sudden cardiac death in newly-diagnosed patients with Parkinson's disease?
P
Population
214,962 newly-diagnosed patients with Parkinson's disease (PD)
I
Intervention
Domperidone use
C
Comparator
No use of domperidone
O
Outcome
Ventricular tachyarrhythmia and sudden cardiac death (VT/SCD)hard clinical
Domperidone use in patients with Parkinson's disease may increase the risk of ventricular tachyarrhythmia and sudden cardiac death, especially in those with pre-existing cardiovascular disease.
Limitations
- imprecision in identifying VT/SCD events
Cite This Study
Renoux et al. (2016) studied this question.